Applications by Sector
Laboratory HVAC
High-precision systems for research, analysis, metrology and quality control
High-precision HVAC systems for research, clinical analysis, metrology and quality control laboratories. ±0.5°C temperature control, ±3% RH relative humidity, F7 to HEPA H14 filtration and configurable differential pressurization. Compliance with ISO 17025, ISO 15189, ANVISA RDC 302, biosafety standards (NB2/NB3/NB4) and INMETRO accreditation requirements. Solutions for pharmaceutical, biotechnology, chemical, environmental and calibration laboratories.
Talk to SpecialistTechnical Specifications
Process Requirements
Controlled environment for hematological, biochemical, immunological and hormonal analyses. Sectorization by technical area (biochemistry, hematology, immunology, urinalysis) with specific requirements for each sector.
Calibration of measurement instruments with metrological traceability. Environment with exceptional thermal stability for dimensional, mass, volume and electrical measurements. ISO 17025 and INMETRO compliance.
Negative pressure environment for microorganism containment. Seeding, incubation, reading and disposal areas with unidirectional flow. Class II biological safety cabinets.
Pre-PCR, amplification and post-PCR areas physically separated with pressure cascade to prevent cross-contamination. HEPA filtration and unidirectional flow in critical areas.
Mass spectrometers, chromatographs (HPLC, GC), atomic absorption spectrometers and heat-sensitive equipment. Thermal stability essential for analytical precision.
Work with moderate-risk agents. Negative pressure relative to corridor, HEPA filtration on exhaust, class II biological safety cabinets. Barrier autoclave.
Work with high-risk agents (tuberculosis, emerging viruses). Staged negative pressure, double HEPA filtration on exhaust, airlock with interlock. Effluent decontamination.
Physicochemical, microbiological and instrumental analyses of raw materials and finished products. Compliance with GLP (Good Laboratory Practice) and validation requirements.
Development of new products and processes. Flexibility for different types of tests and experiments. Synthesis, formulation and characterization areas.
Climatic chambers for drug stability studies per ICH (zones I-IV). Continuous monitoring with validated dataloggers.
Environment with minimal vibration and air currents for precision analytical weighing. Semi-micro and micro balances with 0.001 mg to 0.01 mg resolution.
Receiving, sorting, aliquoting and sample preparation area. Fume hoods for handling solvents and volatile reagents.
Glassware washing and material sterilization area. Heat and humidity exhaust from autoclaves and ovens. Separation between dirty and clean areas.
Environment for animal breeding and experimentation. Negative pressure, 15-20 air changes/hour, HEPA filtration. Photoperiod and ammonia control.
Technical Analysis
Laboratory HVAC: Precision and Compliance
Laboratories are environments where air quality and environmental control are fundamental for reliable results, professional safety, and regulatory compliance. An inadequate HVAC system can compromise years of research, invalidate analyses, and jeopardize laboratory accreditation.
Environmental Impact on Analytical Results
Environmental variations directly affect the precision and accuracy of analyses:
- Temperature: A variation of 1°C can cause an error of 0.1-0.5% in volumetric measurements. Analytical equipment has specific operating ranges.
- Humidity: Affects weighing (moisture absorption), reagent stability, and microbial growth. High humidity causes condensation on equipment optics.
- Particulates: Sample contamination, interference in optical analyses, and risk of cross-contamination.
- Pressure: Inadequate pressurization allows entry of contaminants or escape of biological agents.
Laboratory Classification by Environmental Requirements
| Laboratory Type | Temp. (°C) | UR (%) | Classe ISO |
|---|---|---|---|
| Dimensional Metrology | 20 ±0,5 | 50 ±5 | ISO 7-8 |
| Clinical Analyses | 20-25 ±1 | 40-60 | ISO 8 |
| Molecular Biology (PCR) | 20-24 ±1 | 40-55 | ISO 7 |
| Cell Culture | 20-24 ±1 | 40-60 | ISO 5-7 |
| Pharmaceutical Quality Control | 20-25 ±1 | 45-55 | ISO 7-8 |
| Biosafety NB3 | 20-24 ±2 | 40-60 | ISO 7 |
Qualification of HVAC Systems for Laboratories
In regulated laboratories, the HVAC system must be formally qualified:
- IQ (Installation Qualification): Verification that the system has been installed according to specifications and design.
- OQ (Operational Qualification): Functional tests demonstrating that the system operates within specified parameters.
- PQ (Performance Qualification): Extended monitoring demonstrating the ability to maintain conditions in real operation.
- Periodic Requalification: Annual verification or after significant changes.
Continuous Environmental Monitoring
Accredited laboratories must demonstrate environmental control through:
- Calibrated dataloggers with traceable certificate
- Continuous recording of temperature and humidity (minimum every 15 minutes)
- Alarms for deviations outside specification
- Data backup for a defined period (usually 5-10 years)
- Periodic reports for audits
Sector Challenges
Metrology and instrumental analysis laboratories require ±0.5°C or better stability. Minimal variations can invalidate calibrations and high-precision analyses.
Relative humidity affects analytical weighing, reagent stability, microbial growth and optical equipment operation. ±3-5% RH control is frequently required.
Particulate contaminants can compromise samples, interfere with optical analyses and cause cross-contamination. ISO 5-8 classification per application.
BSL-2/BSL-3 laboratories require negative pressure, HEPA filtration on exhaust and backup systems to prevent pathogen escape.
Mass spectrometers, chromatographs and other analytical equipment cost hundreds of thousands and are sensitive to environmental conditions.
Accredited (ISO 17025, ISO 15189) and regulated (ANVISA, INMETRO) laboratories must demonstrate documented environmental control with traceability.
HVAC systems in pharmaceutical and clinical laboratories require formal qualification (IQ/OQ/PQ) and periodic requalification.
Chemical fume hoods and biological safety cabinets require adequate air replacement to maintain pressure and safety.
Many laboratories operate 24/7 with long-duration experiments. HVAC failures can compromise months of work.
Laboratories are major energy consumers due to high air renewal and precise control. Optimization is essential for sustainability.
Our Solutions
Precision climate control with ±0.5°C temperature and ±3% RH humidity control. Ideal for metrology, analytical instrumentation and cleanroom laboratories.
View ProductChilled water cooling with high precision and low noise for laboratory fan coils and AHUs. Redundancy available.
View ProductAir handling units with high-efficiency filtration (F7 to HEPA H14), humidity control and precise pressurization for different containment levels.
View ProductDedicated cooling for specific analytical equipment such as mass spectrometers, ICP and chromatography systems.
View ProductTemperature control for thermostatic baths, reactors, chromatographic columns and process equipment. Range from -40°C to +250°C.
View ProductHumidity control in weighing rooms, reagent storage and sample preparation areas. Capacities from 5 to 100 kg/h.
View ProductHelioCloud platform for continuous monitoring of temperature, humidity and differential pressure with calibrated and certified dataloggers.
View ProductComplete climate control for biosafety laboratories with negative pressure, double HEPA filtration and backup systems.
View ProductRegulations and Standards
Benefits for Your Business
Success Case
Pharmaceutical Quality Control Laboratory - Campinas/SP
Complete HVAC project for a multinational pharmaceutical industry quality control laboratory. The laboratory includes physicochemical analysis, microbiology, molecular biology, stability and metrology areas. The project was developed to meet ANVISA RDC 17, ISO 17025 and international headquarters audit requirements. The solution included redundant chilled water system, AHUs with HEPA filtration for critical areas, precision CRAC for instrumentation room, environmental monitoring system with 45 points and complete qualification (IQ/OQ/PQ).
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